Which system requires personal protective equipment (PPE) to be worn for contact with all body fluids?

Body Substance Isolation (BSI) is a system that requires the use of personal protective equipment (PPE) for contact with all body fluids. This approach emphasizes the use of barriers—such as gloves, masks, gowns, and eye protection—regardless of the specific type of fluid encountered. The principle behind BSI is to treat all bodily substances as potentially infectious and to take precautionary measures accordingly. This systemic approach ensures that caregivers and medical personnel are protected from exposure to a wide range of pathogens that may be present in various body fluids.

In contrast, Standard Precautions incorporate elements similar to BSI but focus primarily on blood and certain body fluids known to carry infectious agents. Infection Control Guidelines encompass broader practices for preventing the spread of infections in a healthcare setting but may not specifically mandate PPE for all body fluids. Bloodborne Pathogen Standards are focused specifically on the prevention of diseases transmitted through blood and certain other fluids, but do not extend the requirement for PPE to all body fluids indiscriminately. Thus, BSI's comprehensive framework for using PPE for all body fluids makes it the correct answer.